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男性每 2 0人中就有一位患不育症 ,男性不育症中至少 3 0 %存在基因缺陷。生育基因涉及睾丸发育、精子发生、内分泌和旁分泌的调节。关于精子发生 ,尤其应关注Yq11区 ,这里分布着一些精子发生基因。随着ICSI的出现和分子生物学技术的发展 ,人们发现基因缺陷影响了精子发生 ,继而引起不育。而ICSI虽为男性不育症的治疗带来了希望 ,但也可能使这种遗传缺陷传给下一代 ,因此对基因缺陷的检测并避免传给下一代是迫切要解决的问题
One in 20 males suffer from infertility and at least 30% of male infertility has genetic defects. Fertility genes involved in testicular development, spermatogenesis, endocrine and paracrine regulation. With regard to spermatogenesis, particular attention should be paid to the Yq11 region, where some of the spermatogenic genes are distributed. With the advent of ICSI and the development of molecular biology techniques, it has been discovered that genetic defects affect spermatogenesis and subsequently cause infertility. While ICSI offers hope for the treatment of male infertility, it may also pass on this genetic defect to the next generation, so the detection of genetic defects and avoidance to the next generation are urgent problems to be solved