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目的探讨局部应用沙培林治疗乳腺癌根治术后腋窝积液的疗效及安全性。方法选取2010年6月至2014年5月收治的579例乳腺癌患者,均接受了乳腺癌根治术或改良根治术。随机分为治疗组(312例)和对照组(287例),治疗组患者术中给予沙培林局部浸泡15min后,应用沙培林对淋巴结清扫区进行多点注射,并将沙培林药液浸泡过的少量可吸收止血海绵填塞于腋窝局部。对照组患者术中不使用沙培林,单纯生理盐水冲洗术野。比较两组患者术后的伤口疼痛平均持续时间、疼痛程度,腋窝引流量和引流管留置时间等。结果与对照组相比,治疗组的平均腋窝引流总量及术后引流管中位留置时间均明显低于对照组,差异有统计学意义(P<0.05)。而两组患者的术后伤口疼痛平均持续时间、疼痛程度以及术后发热发生率比较,差异无统计学意义(P>0.05)。结论乳腺癌患者术中局部应用沙培林能有效预防和治疗腋窝积液,缩短术后恢复时间。
Objective To investigate the efficacy and safety of topical application of sappalin in the treatment of axillary effusion after radical operation of breast cancer. Methods 579 cases of breast cancer who were admitted from June 2010 to May 2014 were enrolled in this study. All of them received radical mastectomy or modified radical mastectomy. Randomly divided into treatment group (312 cases) and control group (287 cases). The patients in the treatment group were treated with shapleilin locally for 15 minutes after operation, and then samplin was injected into the lymph node dissection area, Liquid soaked in a small amount of absorbable hemostatic sponge stuffed in the axillary local. Patients in the control group did not use saperilin during operation, and only received saline. The average duration of wound pain, the degree of pain, the amount of axillary drainage and the drainage tube indwelling time were compared between the two groups. Results Compared with the control group, the mean axillary drainage and postoperative drainage catheter postoperatively in the treatment group were significantly lower than those in the control group (P <0.05). The average duration of postoperative wound pain, the degree of pain and the incidence of postoperative fever were not significantly different between the two groups (P> 0.05). Conclusion Local application of sapirin in patients with breast cancer can effectively prevent and treat axillary effusion and shorten the recovery time after operation.