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对２０例幽门螺杆菌（ＨＰ）阳性患者，随机分为两组，分别以得乐冲剂（Ｄｅ－Ｎｏｌ，即胶态次枸橼酸铋，ＣＢＳ）和整肠生治疗３周，观察其ＨＰ的清除率。同时用氢化物原子荧光法测定治疗前后血液及胃液铋浓度并测定胃液ｐＨ值。结果：ＣＢＳ组ＨＰ清除率为５０％，治疗后血液及胃液铋浓度较治疗前均有显著升高（Ｐ＜０．０５），胃液ｐＨ值显著升高（Ｐ＜０．０１）。整肠生组ＨＰ清除率为２０％，治疗后血液铋浓度及胃液ｐＨ值较治疗前均无显著变化（Ｐ＞０．０５），但胃液铋浓度明显降低（Ｐ＜０．０５）。提示：胃液铋浓度是清除ＨＰ的关键，其最适浓度为５６μｇ／Ｌ。
Twenty patients with positive Helicobacter pylori (HP) were randomly divided into two groups and treated with De-Nol (colloidal bismuth subhitum citrate, CBS) Clearance rate. At the same time, the concentrations of bismuth in blood and gastric juice before and after treatment were measured by hydride atomic fluorescence spectrometry and the pH value of gastric juice was measured. Results: The clearance rate of HP in CBS group was 50%. After treatment, the concentrations of bismuth in blood and gastric juice were significantly higher than those before treatment (P <0.05) and the pH value in gastric juice was significantly increased (P <0.01). There was no significant change in the blood bismuth concentration and gastric juice pH value after treatment (P> 0.05), but the concentration of bismuth in gastric juice was significantly decreased (P <0.05). Tip: The concentration of gastric juice bismuth is the key to clear HP, the optimum concentration of 56μg / L.