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研究蒿属植物毛莲蒿地上部分倍半萜类化学成分,通过硅胶柱色谱、反相硅胶柱色谱、制备高效液相色谱等色谱方法分离得到12个倍半萜类成分,经多种波谱方法鉴定其结构,分别为negunfurol(1),schensianol A(2),artemine(3),eudesm-4(14)-en-12-oic acid,erivanin(4),1,5-diepi-artemin(5),acetylartemin(6),naphtho[1,2-b]furan-2(3H)-one,6-(acetyloxy)-decahydro-9a-hydroxy-3,5a-dimethyl-9-methylene-(3S,3aS,5aS,6S,9aS,9bS)(7),naphtho[1,2-b]furan-2(3H)-one,6-(acetyloxy)-3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,5a,9-trimethyl-(3S,3aS,5aR,6S,8S,9bS)(8),isoerivanin(9),barrelierin(10),(11S)-1-oxoeudesm-4(14)-eno-13,6α-lactone(11),1-epi-dehydroisoeranin(12)。其中化合物1和2为首次从蒿属植物中分离得到,其它化合物均为首次从毛莲蒿中分离得到。
The chemical constituents of aerial parts of Artemisia selengensis were studied. Twelve sesquiterpenoids were isolated by silica gel column chromatography, reverse phase silica gel column chromatography and preparative high performance liquid chromatography. The compounds were identified by many spectral methods The structures were negunfurol (1), schensianol A (2), artemine (3), eudesm-4 (14) -en- 12-oic acid, erivanin (4), 1,5-diepi-artemin acetylartemin (6), naphtho [1,2-b] furan-2 (3H) -one, 6- (acetyloxy) -decahydro-9a-hydroxy-3,5a-dimethyl- Naphtho [1,2-b] furan-2 (3H) -one, 6- (acetyloxy) -3a, 4,5,5a, 6,7,8,9b- octahydro-8-hydroxy-3,5a, 9-trimethyl- (3S, 3aS, 5aR, 6S, 8S, 9bS) (8), isoerivanin (9), barrelierin (10), (11S) -1-oxoeudesm-4 (14) -eno-13,6α-lactone (11), 1-epi-dehydroisoeranin (12). Among them, compounds 1 and 2 were isolated from Artemisia for the first time, and other compounds were isolated from Artemisia annua for the first time.