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[目的]建立顶空固相微萃取-气相色谱法测定尿中五氯酚的方法。[方法]利用顶空固相微萃取技术,富集尿中五氯酚,优化萃取条件和色谱柱,利用电子捕获检测器测定。[结果]该方法测定范围为0.50~5.00 mg/L,相关系数r=0.999 3,检出限为0.09 mg/L,平均回收率为97.6%~103.7%,精密度为1.63%~6.78%。[结论]顶空固相微萃取技术处理尿样简便快速,检出限低,结果准确可靠,可用于职业接触五氯酚人群尿中五氯酚的测定。
[Objective] To establish a method for the determination of pentachlorophenol in urine by headspace solid-phase microextraction-gas chromatography. [Method] The headspace solid phase microextraction technique was used to enrich pentachlorophenol in urine and optimize extraction conditions and chromatographic column. The electron capture detector was used for the determination. [Result] The determination range was 0.50-5.50 mg / L, the correlation coefficient was 0.999 3, the detection limit was 0.09 mg / L, the average recoveries were 97.6% -103.7% and the precision was 1.63% -6.78%. [Conclusion] The headspace solid-phase microextraction technology is simple and rapid, and the detection limit is low. The results are accurate and reliable and can be used for the determination of pentachlorophenol in the urine of occupational exposure pentachlorophenol population.