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近年来,已发现环磷酸腺苷(C-AMP)的测定对某些疾病的诊断和治疗有着重要的参考价值。某些肿瘤、内分泌疾病时c-AMP含量的改变已有报道。近年有人报道,阻塞性黄疸与非阻塞性黄疽注射胰高血糖素(Glucagon)后,血浆c-AMP含量的升高有区别。因胰高血糖素可活化细胞膜上的腺苷酸环化酶,使C-AMP增加,而引起血浆C-AMP含量明显升高。为了进一步证实这一结果的正确性及掌握其变化规律,以便更好地应用于临床,故在动物上进行了实验性研究。现将实验方法及初步结果报告如下:
In recent years, it has been found that the measurement of cyclic adenosine monophosphate (C-AMP) has important reference value for the diagnosis and treatment of certain diseases. Changes in c-AMP levels in some tumors and endocrine diseases have been reported. It has been reported in recent years that the increase of plasma c-AMP levels is different between obstructive jaundice and non-obstructive jaundice after glucagon injection. Because glucagon can activate adenylyl cyclase on the cell membrane, C-AMP increases, causing a significant increase in plasma C-AMP levels. In order to further confirm the correctness of this result and to grasp its changing rules so as to be better applied to the clinic, an experimental study was conducted on animals. The experimental method and preliminary results are now reported as follows: