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目的 探讨CD4 4v6和C myc在膀胱移行细胞癌中的表达及其临床意义。方法 应用免疫组化法检测 5 0例膀胱移行细胞癌标本中CD4 4v6和C myc的表达情况、并与膀胱癌的病理分级及随访结果相比较。 结果 2 8例CD4 4 v6表达阳性 ,阳性率 5 6 % ,且膀胱癌分化越好 ,CD4 4v6表达率越高 ,临床预后亦较好 ,这与其它肿瘤具有很大区别。 36例C myc表达阳性 ,阳性率 72 % ,膀胱癌分化越差 ,表达率越高 ,临床预后也较差。结论 CD4 4v6和C myc表达可以作为监测膀胱移行细胞癌恶性程度及预后的重要指标。
Objective To investigate the expression of CD4 4v6 and C-myc in bladder transitional cell carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of CD4 4v6 and C-myc in 50 bladder transitional cell carcinoma samples and compared with the pathological grading and follow-up results of bladder cancer. Results The positive rate of CD4 4 v6 in 28 cases was 56%. The better the differentiation of bladder cancer was, the higher the expression of CD4 4v6 was and the better prognosis was, which was different from other tumors. 36 cases of C myc positive expression, the positive rate of 72%, the worse the differentiation of bladder cancer, the higher the rate of expression, the clinical prognosis is poor. Conclusion The expression of CD4 4v6 and C-myc can be used as an important indicator to monitor the malignant degree and prognosis of transitional cell carcinoma of the bladder.