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目的 探讨不同剂量米非司同治疗子宫肌瘤的疗效及对性激素的影响。方法 随子宫肌瘤患者分两组 ,服用不同剂量米非司酮 3～ 6个月。B超测量子宫及肌瘤大小 ,用放免法测定性激素水平。结果 治疗后闭经、临床症状明显改善 ,A组肌瘤体积于服药后 3个月时平均缩小 52 56 % ,6个月时平均缩小 6 1 6 9% ;B组分别为缩小 4 8 6 1%及 52 12 %。治疗 6个月有显著性差异 (P <0 0 5) ,并呈时间依赖性。两组治疗后estradiol(E2 )和Progestagen(P)下降明显 (P <0 0 1)。 结论 米非司酮治疗子宫肌瘤疗效肯定 ,副作用小 ,为保守治疗子宫肌瘤开辟了一条新途径。并以服米非司酮 2 5mg/d为较理想的治疗剂量。
Objective To investigate the efficacy of different doses of Microfloxacin in the treatment of uterine fibroids and its effects on sex hormones. Methods Patients with uterine fibroids were divided into two groups, taking different doses of mifepristone 3-6 months. B-measurement of uterine and fibroid size, radioimmunoassay determination of sex hormone levels. Results After amenorrhea, the clinical symptoms were significantly improved. The volume of fibroids in group A decreased 52 56% on average at 3 months and 6 1 6 9% on 6 months, while the volume of group A decreased 4 8 6 1% And 52 12%. There was a significant difference (P <0 05) for 6 months of treatment, which was time-dependent. The estradiol (E2) and Progestagen (P) decreased significantly in both groups after treatment (P <0.01). Conclusion The efficacy of mifepristone treatment of uterine fibroids positive side effects, for the conservative treatment of uterine fibroids has opened up a new way. And to take mifepristone 25mg / d is the ideal therapeutic dose.