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用两根玻璃微电极同时记录大鼠脑不同部位中痛兴奋神经元(PEN)和痛抑制神经元(PIN)的放电,系统、深入地研究脑室、蛛网膜下腔或核团内注射乙酰胆碱(Ach)、单胺类递质(DA、NE、5-HT)和γ-氨基丁酸(GABA)等神经递质及其相应的拮抗剂对脑不同部位中PEN和PIN电活动的影响。实验结果证明:(1)脑室注射Ach不仅使丘脑两侧束旁核或一侧束旁核和中脑网状结构中PEN的放电减少,潜伏期延长;同时还使PIN的抑制时程缩短,放电增加,两者的电活动相互配合,呈现出
Two glass microelectrodes were used to simultaneously record the discharge of pain-stimulating neurons (PEN) and pain-inhibiting neurons (PIN) in different parts of the rat brain, and to systematically study the intracerebroventricular, subarachnoid or intracranial injection of acetylcholine Ach, monoamine neurotransmitters (DA, NE, 5-HT) and γ-aminobutyric acid (GABA) and their antagonists on the activity of PEN and PIN in different parts of the brain. Experimental results show that: (1) Ach injection not only reduces the discharge of PEN in the parafascicular nucleus or parabronchial nucleus and midbrain reticular structures on both sides of the thalamus, but prolongs the incubation period; meanwhile, it also shortens the inhibitory duration of PIN and discharges Increase, the two of the electrical activities cooperate with each other, showing