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目的：探讨不同剂量的中药黄芪对顺铂所致肾毒性的防护作用，以期指导临床改变目前高剂量顺铂必须水化的现状。方法：以７ ｍｇ·ｋｇ－１ 顺铂单次腹腔注射建立小鼠的肾损模型，于实验的第１～７ 天分别给予不同剂量的黄芪腹腔注射。评估小鼠血尿素氮、血肌酐、血ＮＡＧ酶及肾脏病理学改变。同样的方法实验Ｓ１８０ 荷瘤小鼠并评估瘤重。结果：不同剂量的黄芪均能明显改善顺铂所致小鼠血尿素氮、血肌酐、血ＮＡＧ酶的增高，并与黄芪的剂量正相关。但当黄芪剂量增加到一定数值，其保护作用稳定，对顺铂的抗肿瘤活性均无影响。获病理学支持。结论：黄芪确能防护顺铂所致的肾毒性且不影响其抗瘤活性
OBJECTIVE: To investigate the protective effect of different doses of Astragalus membranaceus on nephrotoxicity induced by cisplatin in order to guide clinical changes in the current status of high-dose cisplatin that must be hydrated. METHODS: The renal injury model of mice was established by single intraperitoneal injection of 7 mg·kg-1 cisplatin. Different doses of astragalus were intraperitoneally injected on the first to seventh days of the experiment. Blood urea nitrogen, serum creatinine, blood NAG enzymes, and pathological changes in the kidneys were evaluated. In the same manner, S180 tumor-bearing mice were tested and evaluated for tumor weight. RESULTS: Different doses of Astragalus membranaceus could significantly improve the blood urea nitrogen, serum creatinine and blood NAG enzyme levels in mice induced by cisplatin, and were positively related to the dose of Astragalus membranaceus. However, when the dose of Astragalus membranaceus was increased to a certain value, its protective effect was stable and had no effect on the antitumor activity of cisplatin. Pathological support. Conclusion: Astragalus can protect against nephrotoxicity induced by cisplatin without affecting its antitumor activity.