近年来,国内应用柠檬酸铝治疗矽肺在动物实验和临床上均取得一定效果。为探讨该药治疗矽肺的作用是否与抗石英对巨噬细胞的毒作用有关,进行了正常大鼠肺泡巨噬细胞体外培养的实验。取健康大鼠经气管灌洗获取肺泡巨噬细胞,实验用北京石英粉尘粒子小于2微米者95%以上,含游离SiO_297%,柠檬酸铝为北京医学院提供注射 In recent years, domestic application of aluminum citrate for the treatment of silicosis has achieved certain results in animal experiments and clinics. In order to investigate whether the drug’s effect on silicosis is related to the toxic effect of anti-quartz on macrophages, experiments on in vitro culture of normal rat alveolar macrophages were performed. Rats with alveolar macrophages were obtained by tracheal lavage in healthy rats. More than 95% of Beijing quartz dust particles were smaller than 2 microns in size, containing free SiO_297%, and aluminum citrate was injected into Beijing Medical College.