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目的:1.建立犬食管气管瘘动物模型;2.观察食管壁双瓣修补气管缺损术局部组织病理学改变、愈合情况及该术式的治疗效果。方法:犬16只,随机分为2组,实验组(12只)建立犬食管气管瘘动物模型,行食管壁双瓣修补气管缺损术,对照组(4只)正常犬作为空白对照,术后支气管镜检查,术后1,2,8周处死动物,观察实验动物一般情况、修补局部的大体改变和组织病理学改变,测定气管狭窄指数。结果:成功建立了犬食管气管瘘动物模型;食管双瓣修补术后,实验组动物呛咳症状消失,均存活至预定时间,修补瓣和气管之间愈合良好,修补瓣血供良好,未出现气管狭窄情况,气管通畅度良好。结论:通过手术方式建立食管气管瘘模型方法可靠;食管双瓣修补术治疗TEF效果良好,值得进一步研究及推广。
Objective: 1. To establish animal model of canine esophageal fistula; 2. To observe the local histopathological changes and healing of tracheal defect treated by double-flap esophageal wall repair and the therapeutic effect of the operation. Methods: Twenty-six dogs were randomly divided into two groups. The experimental group (12 rats) was established animal model of canine esophageal tracheal fistula. Tracheal defect was treated by double-flap esophageal wall. The control group (4) normal dogs served as blank control After bronchoscopy, the animals were sacrificed at 1, 2, and 8 weeks after operation. The general conditions of the experimental animals were observed, the general changes in local and histopathological changes were repaired, and the tracheal stenosis index was determined. Results: Animal models of canine esophageal tracheal fistula were established successfully. After the esophageal flap was repaired, the symptoms of cough in the experimental group disappeared and all survived to the scheduled time. The repaired flap and the trachea healed well, and the repaired flap blood supply was good and did not appear Tracheal stenosis, tracheal patency is good. Conclusion: The method of esophageal tracheal fistula established by operation is reliable. The treatment of TEF by double esophageal flap repair is effective and worthy of further study and promotion.