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Objective:To investigate vascular endothelial growth factor(VEGF) expression and microvessel density(MVD) on the fibromyoma uteri treated with mifepristone.Methods:VEGF expression and MVD were counted on 60 cases of the fibromyoma uteri by SP method,including 40 cases of mifepristone treated and 20 cases of untreated patients as controlled group.Results:VEGF positive expression rate and MVD in treated group were 37.5% and 9.90 ± 5.95,which were lower than those in controlled group(80% and 16.36 ± 2.07;P < 0.05).Meanwhile,in treated group,those in marked shrink in tumor size sub-group were lower than in not obvious sub-group(12.0% and 7.89 ± 4.36 vs.80% and 11.29 ± 3.10;P < 0.05).Conclusion:VEGF and MVD expression decreases in the fibromyoma uteri after treatment with mifepristone,suggesting that mifepristone could inhibit angiogenesis and blood supply resulting in tumor shrink.
Objective: To investigate vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) on the fibromyoma uteri treated with mifepristone. Methods: VEGF expression and MVD were counted on 60 cases of the fibromyoma uteri by SP method, including 40 cases of mifepristone treated and 20 cases of untreated patients as controlled group. Results: VEGF positive expression rate and MVD in treated groups were 37.5% and 9.90 ± 5.95, which were lower than those in controlled group (80% and 16.36 ± 2.07; P <0.05) .Meanwhile, in treated group, those in marked shrink in tumor size sub-group were lower than in not obvious sub-group (12.0% and 7.89 ± 4.36 vs. 80% and 11.29 ± 3.10; P <0.05) .Conclusion: VEGF and MVD expression decreases in the fibromyoma uteri after treatment with mifepristone, suggesting that mifepristone could inhibit angiogenesis and blood supply resulting in tumor shrink.