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目的观察B族维生素治疗急性脑梗死前后患者血清同型半胱氨酸(Hcy)的变化,评估其对脑梗死患者神经功能恢复的影响。方法选择急性脑梗死患者90例,根据治疗方法分为2组,对照组:给予抗血小板、改善循环等常规治疗;观察组:在对照组常规治疗基础上,给予B族维生素治疗。4周后比较两组患者治疗前后血清Hcy浓度的变化,进行神经功能缺损评分(NIHSS)。结果观察组治疗后血清Hcy浓度及NIHSS均明显低于治疗前及对照组治疗后(均P<0.05);血清Hcy浓度及NIHSS之间无明显相关性(P>0.05)。结论 B族维生素有助于降低血清Hcy,改善急性脑梗死患者的神经功能。
Objective To observe the changes of serum homocysteine (Hcy) in patients with B-type vitamins before and after acute cerebral infarction and evaluate its effect on the recovery of neurological function in patients with cerebral infarction. Methods Ninety patients with acute cerebral infarction were selected and divided into two groups according to the treatment method. The control group was given antiplatelet therapy and routine therapy such as circulation improvement. The observation group was treated with B vitamins on the basis of routine treatment in the control group. After 4 weeks, the change of serum Hcy level in both groups was compared before and after treatment, and neurological deficit score (NIHSS) was compared. Results After treatment, serum Hcy concentration and NIHSS in the observation group were significantly lower than those before treatment and in the control group after treatment (all P <0.05). There was no significant correlation between serum Hcy concentration and NIHSS (P> 0.05). Conclusion B vitamins help to reduce serum Hcy and improve neurological function in patients with acute cerebral infarction.