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目的:对研发的鼻咽癌(NPC)患者生存质量量表(QOL-NPC)进行信度和效度评价。方法:2007-01-21-2007-02-07,统一受训的调查员对433例确诊的、接受放疗的NPC患者进行调查,并采用相关分析、信度分析、因子分析和结构方程模型等统计方法进行分析。结果:QOL-NPC量表具有较好的分半信度和内部信度;除社会领域外(信度系数为0.628),各领域的内部信度系数均>0.8。每条目跟所属领域的相关系数>0.547,均有统计学意义,大于该条目与其他领域的相关系数,说明QOL-NPC量表有良好的内容效度。所有条目提取的6个主成分分布代表了各个领域,累计贡献达57.04%;结构方程模型拟和效果好,各条目和相关领域关系与量表的理论结构假设基本一致,结构效度较好。不同性别、不同放疗阶段患者的PS领域得分差异有统计学意义(t=2.10,P=0.037;F=3.34,P=0.019),不同收入人群的PH、PS、SE领域得分差异有统计学意义,P<0.05。结论:QOL-NPC量表有较好的信度和效度,可用于评价正在或者已经接受放疗NPC患者的生存质量。
Objective: To evaluate the reliability and validity of the developed QOL-NPC in patients with nasopharyngeal carcinoma (NPC). Methods: 2007-01-21-2007-02-07, a unified training of investigators on 433 cases of patients diagnosed with radiotherapy NPC were investigated and using correlation analysis, reliability analysis, factor analysis and structural equation modeling and other statistics Method for analysis. Results: The QOL-NPC scale had good semi-reliability and internal reliability. In addition to the social field (reliability coefficient was 0.628), the internal reliability coefficients of all the areas were> 0.8. The correlation coefficient of each item with its own field is more than 0.547, which is statistically significant and larger than the correlation coefficient between this item and other fields, indicating that the QOL-NPC scale has good content validity. The six principal component distributions extracted from all the entries represent the various fields, with a total contribution of 57.04%. The structural equation modeling has a good fitting effect. The relationship between each entry and related fields is basically consistent with the theoretical structure assumption of the scale, and the structural validity is good. PS scores of patients in different genders and radiotherapy stages were significantly different (t = 2.10, P = 0.037; F = 3.34, P = 0.019). There were significant differences in PH, PS and SE scores among different income groups , P <0.05. Conclusion: The QOL-NPC scale has good reliability and validity and can be used to evaluate the quality of life of patients who are undergoing or have already received radiotherapy.