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目的 :探讨PCNA和C -erbB - 2在大肠癌发病中的作用及其与病理分级 ,临床分期及预后的关系。方法 :应用免疫组化SP法对 5 2例大肠癌组织及癌旁粘膜进行检测。结果 :PCNA和C -erbB - 2在大肠癌组织均呈高表达 (P <0 0 5 ) ;与病理分级、临床分期及预后密切相关。结论 :PCNA和C -erbB - 2在大肠癌的发生和发展过程中起重要作用 ,提示PCNA和C -erbB - 2可作为判断大肠癌预后的标记物。
Objective: To investigate the role of PCNA and C-erbB-2 in the pathogenesis of colorectal cancer and its relationship with pathological grade, clinical stage and prognosis. Methods: Immunohistochemical SP method was used to detect 52 cases of colorectal cancer tissues and adjacent mucosa. Results: The expressions of PCNA and C-erbB-2 in colorectal cancer tissues were both high (P <0.05), which were closely related to the pathological grade, clinical stage and prognosis. Conclusion: PCNA and C-erbB - 2 play an important role in the carcinogenesis and progression of colorectal cancer, suggesting that PCNA and C-erbB - 2 may be useful markers for the prognosis of colorectal cancer.