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目的 促进肿瘤诊断试验评价质量的提高。 方法 采用整群抽样调查了《中华肿瘤杂志》90年代刊载的临床诊断试验论著。 结果 在调查的 2 3篇论著中 ,免疫学诊断试验占比重最大 ,为 39 1% (9/2 3) ,其次为生化学、影像学检查 ,分别占 17 4% (4 /2 3)、13 0 % (3/2 3) ;金标准明确可靠者占 82 6 % (19/2 3) ,正确计算灵敏度及特异度者占 6 0 9% (14/2 3) ,采用盲法者占 39 1% (9/2 3) ;符合全部 7条方法学标准者仅为 4 3 % (1/2 3) ,符合 7条方法学标准中 4条以上者为 5 6 5 % (13/2 3) ,仅符合 1条方法学标准者为 8 7% (2 /2 3)。 结论 诊断试验评价的方法学标准受到了一定程度重视 ,肿瘤诊断试验论著质量有待提高与完善。
Objective To promote the improvement of the quality of tumor diagnostic test evaluation. Methods A cluster sampling survey of clinical diagnostic test published in the Chinese Journal of Oncology in the 1990s was conducted. RESULTS: Of the 23 articles reviewed, immunological diagnostic tests accounted for the largest proportion, 39 1% (9/2 3), followed by biochemical and radiographic examinations, accounting for 17 4% (4/23) respectively. 130% (3/2 3); 82.6 % (19/2 3) of the clear and reliable gold standard, and 60% (14/2 3) of the correct sensitivity and specificity were calculated. 39 1% (9/2 3); only 4 3 % (1/2 3) of the participants met all 7 methodological criteria, and 5 6 5 % of those who met 4 of the 7 methodological criteria (13/2). 3) Only 87% (2 / 2 3) of the respondents met the criteria for a methodology. Conclusion The methodological criteria for the evaluation of diagnostic tests have received a certain degree of emphasis. The quality of tumor diagnosis tests should be improved and improved.