丙烯酸甲酯(下称甲酯),丙烯酸乙酯(下称乙酯)是两种易挥发且具有强烈异味的不饱和酯。目前被广泛用于塑料、涂料、皮革、纺织品等的加工中。Joseph F,Treon等曾报道过这二种酯的经口、经皮及吸入毒性。当达到一定剂量时,三种染毒途经均可导致死亡。在低剂量时可见有各种刺激反应。目前,在国内尚未见到有关报道。为了研究这二种酯的经皮毒性,我们采用雌性豚鼠和家兔进行了实验,现将结果报告如下: Methyl acrylate (hereinafter referred to as methyl ester) and ethyl acrylate (hereinafter referred to as ethyl ester) are two kinds of unsaturated esters which are volatile and have a strong odor. Is currently widely used in plastics, coatings, leather, textiles and other processing. Joseph F, Treon et al. Have reported oral, transcutaneous and inhalation toxicity of these two esters. When reaching a certain dose, all three routes of exposure can result in death. There are a variety of stimuli at low doses. At present, the country has not yet seen the report. In order to study the transdermal toxicity of these two esters, we conducted experiments with female guinea pigs and rabbits. The results are reported as follows: