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实验用紫外线和丝裂霉素 C 作为机体 DNA 损伤的诱变剂,以人体外周淋巴细胞 DNA 非程序合成(UDS)水平、小鼠骨髓细胞诱发姐妹染色单体交换(SCE)频率为指标,分别观察了延缓衰老中药还精煎对人体及小鼠 DNA 损伤修复能力的影响。结果显示,老年人的 UDS 水平低于青年人,服用还精煎老人的 UDS 水平高于自身服药前水平,也高于未服药老寄:组,向青年人水平靠拢;饲喂还精煎小鼠的骨髓细胞诱发 SCE 值明显低于对照组。提示还精煎提高了机体对 DNA 损伤的修复能力,这可能就是药物补肾延衰作用的部分机理所在。
UV and mitomycin C were used as mutagenic agents for DNA damage in humans, and human non-programming DNA (UDS) levels in peripheral lymphocytes and sister chromatid exchange (SCE) frequencies in mouse bone marrow cells were used as indicators. Observed the effect of delaying the aging of traditional Chinese medicines on the repair ability of DNA damage in humans and mice. The results showed that the UDS level of the elderly is lower than that of young people, and UDS levels of those who are taking the fry even older than their own pre-dosage levels are higher than those of the untreated old group: they are closer to the level of young people; Rat bone marrow cells induced SCE was significantly lower than the control group. It is also suggested that refined frying enhances the ability of the body to repair DNA damage, which may be part of the mechanism of the drug’s role in promoting kidney failure.