论文部分内容阅读
目的探讨冠心病患者血浆中氨基末端脑钠肽前体(NT-pro BNP)水平与抑郁障碍的关系。方法选取2015年10月至2016年5月华北理工大学附属唐山工人医院的冠心病患者142例,根据汉密尔顿抑郁量表(HAMD)评分将冠心病患者分为抑郁组与非抑郁组,并测定血浆NT-pro BNP水平。结果冠心病患者抑郁检出率为33.8%;抑郁组与非抑郁组年龄、体重指数、在职情况、血浆NT-pro BNP水平比较差异均有统计学意义(均P<0.05);两组间性别、婚姻状况、疾病类型、发病次数、心功能Killip分级,糖尿病、高血压、高血脂症、脑血管病检出率,心脏手术史及他汀类药物、阿司匹林使用率比较差异均无统计学意义(均P>0.05);多因素Logistic回归分析结果显示,血浆NT-pro BNP水平、体重指数与冠心病患者的抑郁障碍有关(P<0.05)。结论血浆NT-pro BNP水平是冠心病患者抑郁障碍的独立危险因素,有助于冠心病患者发生抑郁障碍的早期预测。
Objective To investigate the relationship between plasma NT-proBNP level and depression in patients with coronary heart disease. Methods From October 2015 to May 2016, 142 patients with coronary heart disease in Tangshan Workers Hospital Affiliated to North China University of Science and Technology were divided into depression group and non-depression group according to the Hamilton Depression Rating Scale (HAMD) NT-pro BNP levels. Results The prevalence of depression in patients with coronary heart disease was 33.8%. There were significant differences in age, body mass index, employment status and plasma NT-pro BNP levels between depression group and non-depression group (all P <0.05) , Marital status, disease type, frequency of onset, Killip grade, diabetes mellitus, hypertension, hyperlipidemia, detection rate of cerebrovascular disease, history of cardiac surgery and statins, aspirin use rates were not statistically significant ( (All P> 0.05). Multivariate logistic regression analysis showed that plasma NT-pro BNP level and body mass index were associated with depression in patients with coronary heart disease (P <0.05). Conclusion Plasma NT-pro BNP level is an independent risk factor for depressive disorder in patients with coronary heart disease and contributes to the early prediction of depressive disorder in patients with coronary heart disease.