以1%甲基硫脲块料饲喂小鼠,8个月后出现明显甲状腺功能低下,镜下呈瘤肿结构,免疫组化胶体金银法显示甲状腺组织内无 T_3和 T_4。透射电镜可见滤泡上皮细胞内质网和线粒体明显病变,部分微绒毛融合短粗的伪足样突起。扫描电镜显示滤泡上皮表面伪足融合呈枯树枝样结构,作者探讨了硫脲性甲状腺瘤肿形成的机制。 Mice were fed with 1% methylthiourea block. Eight months later, there was obvious hypothyroidism. Microscopic examination showed tumor structure. Immunohistochemistry gold and silver showed no T_3 and T_4 in the thyroid tissue. Transmission electron microscopy showed follicular epithelial cells and mitochondria significantly changes in the endoplasmic reticulum, part of the microvilli fusion stubby pseudo-foot-like protrusions. Scanning electron microscopy showed follicular epithelial pseudopodia fusion was dead-tree-like structure, the authors discussed the mechanism of thiourea-type thyroid tumor formation.