间质性肺疾病是指以弥漫性肺泡单位慢性炎症和间质纤维化为主要病理特征的一大组疾病。多种细胞因子构成的复杂的细胞因子网络在间质性肺疾病的发病机制中发挥重要作用。Th1/Th2细胞因子在组织损伤、炎症形成、纤维化的各个阶段有不同作用。化学趋化因子在炎症组织中吸引和激活白细胞亚群,调节血管生成,促进纤维化的形成。 Interstitial lung disease refers to a large group of diseases characterized by chronic inflammation of diffuse alveolar units and interstitial fibrosis as the main pathological features. The complex network of cytokines that make up a wide variety of cytokines play an important role in the pathogenesis of interstitial lung disease. Th1 / Th2 cytokines play different roles in various stages of tissue damage, inflammation and fibrosis. Chemotactic factors attract and activate leukocyte subpopulations in inflammatory tissues, regulate angiogenesis and promote the formation of fibrosis.