论文部分内容阅读
本研究采用多电极记录技术,在离体条件下研究外源性锌离子(Zn2+)对无镁人工脑脊液诱导的Sprague-Dawley大鼠海马切片癫痫样放电的起源、传播与频率特性的调节作用。结果表明:1μmol/L和100μmol/L的Zn2+作用于海马切片,不改变海马切片上癫痫样放电的起始位置,但能够降低癫痫样放电顺行和逆行两个方向的传播速度,并改变癫痫样放电不同频率范围成分所占的比例。以上结果提示,1μmol/L和100μmol/L的Zn2+可以对海马切片上的癫痫样放电起到调节作用,减慢癫痫样放电在网络中的传播速度,同时,可能对神经元放电活动起到去同步化的作用。
In this study, multi-electrode recording technique was used to study the regulatory effect of exogenous zinc ion (Zn2 +) on the origin, transmission and frequency characteristics of epileptiform discharge in hippocampal slices induced by magnesium-free artificial cerebrospinal fluid (CSF) in vitro. The results showed that 1μmol / L and 100μmol / L Zn2 + did not change the starting position of epileptiform discharge in the hippocampal slices, but could reduce the speed of epileptiform discharge in both normal and retrograde directions and change epilepsy Like discharge the proportion of different frequency range components. The above results suggest that 1μmol / L and 100μmol / L of Zn2 + can regulate the epileptiform discharge in the hippocampal slices and slow down the spread of epileptiform discharge in the network, and at the same time, it may play a role in the discharge activity of neurons The role of synchronization.