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目的探讨饮用高砷水对机体尿素氮水平的影响。方法以2个地区(高砷区和对照区)的常住成年居民为调查对象,采集晨尿及空腹静脉血,同时采集受访者家中饮用水水样。用原子吸收法测水总砷,用苦味酸比色法检测尿肌酐,采用酶偶联速率法测尿素氮。结果饮水型砷中毒病区居民血清尿素氮平均水平(5.08 mmol/L)高于非高砷区居民(3.60 mmol/L),二者差异显著(P=0.0239);饮水型砷中毒病区居民饮用水总砷浓度与血清尿素氮水平呈正相关关系(r=0.293,P=0.023)。结论饮用高砷水对居民肾脏存在潜在危害。
Objective To investigate the effect of drinking high-arsenic water on the level of urea nitrogen. Methods The resident residents in two areas (high arsenic area and control area) were enrolled in the study. Morning urine and fasting venous blood were collected. At the same time, drinking water samples from the respondents were collected. Total arsenic was measured by atomic absorption spectrophotometry. Urinary creatinine was detected by picric acid colorimetric method. Urea nitrogen was measured by enzyme coupling rate. Results The mean level of serum urea nitrogen (5.08 mmol / L) in drinking arsenism patients was significantly higher than that in non-arsenic residents (3.60 mmol / L) (P = 0.0239) The total arsenic concentration in drinking water was positively correlated with serum urea nitrogen level (r = 0.293, P = 0.023). Conclusion Drinking high-arsenic water is potentially harmful to the resident kidney.