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目的:研究CathD、CD44 V6和EGFR在非小细胞肺癌(NSCLC)中的表达情况及意义。方法:运用免疫组化法检测56例NSCLC患者癌组织中CathD、CD44 V6和EGFR的表达情况。结果:CathD、CD44 V6和EGFR在NSCLC组织中均有过度表达;而CathD、CD44 V6和EGFR的阳性表达率与组织学类型无关;CathD、EGFR的表达与TNM分期有关,CD44 V6表达与TNM分期无关;CathD、CD44 V6和EGFR的阳性表达率随癌组织分化程度的降低和淋巴结转移的出现而增加;CathD、EGFR和CD44 V6表达之间具有正相关性。结论:CathD、EGFR和CD44 V6在NSCLC的发展中起促进作用;联合检测3种蛋白的表达水平可以作为评价肺癌生物学行为以及判断转移潜能和预后的重要指标。
Objective: To study the expression and significance of CathD, CD44 V6 and EGFR in non-small cell lung cancer (NSCLC). Methods: Immunohistochemistry was used to detect the expression of CathD, CD44 V6 and EGFR in 56 NSCLC patients. Results: The positive rates of CathD, CD44 V6 and EGFR were all over-expressed in NSCLC tissues, while the positive rates of CathD, CD44 V6 and EGFR were not related to the histological type. The expression of CathD and EGFR was related to TNM staging. CD44 V6 expression was correlated with TNM stage . The positive expression rate of CathD, CD44 V6 and EGFR increased with the degree of differentiation and lymph node metastasis. The positive expression of CathD, EGFR and CD44 V6 had positive correlation. Conclusions: CathD, EGFR and CD44 V6 play an important role in the development of NSCLC. The combined detection of three proteins can be used as an important index to evaluate the biological behavior of lung cancer and to evaluate the metastatic potential and prognosis.