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目的 :对克林沙星的抗菌活性进行研究。方法 :克林沙星的最小抑菌浓度 (MIC)检测采用试管肉汤稀释法 ,其半数有效量 (ED50 )的检测通过对感染小鼠的试验性治疗来实现。结果 :克林沙星对嗜麦芽窄食单胞菌以外的全部实验菌的MIC90 为0 .0 3～ 2 .0mg·L-1,低于单次口服克林沙星 2 0 0mg在血浆中的峰浓度 (2 .5mg·L-1) ;克林沙星的MIC值为环丙沙星的 1/ 8～ 1/ 2 ,ED50 为环丙沙星的 1/ 3～ 1。结论 :克林沙星体内体外的抗菌活性较环丙沙星为优 ,是一个广谱高效的新喹诺酮类抗菌药。
Objective: To study the antibacterial activity of clinifloxacin. Methods: The minimum inhibitory concentration (MIC) of clinifloxacin was determined by the test tube broth dilution method. The half-effective dose (ED50) was detected by experimental treatment in infected mice. Results: The MIC90 of clindarix to all experimental bacteria except Stenotrophomonas maltophilia was 0.330 ~ 2.0 mg · L-1, which was lower than the peak concentration of plasma of 200 mg of single oral clinophyte 2.5 mg · L-1). The MIC of clindamycin was 1/8 to 1/2 of that of ciprofloxacin, and the ED50 was 1/3 to 1 of ciprofloxacin. Conclusion: The antibacterial activity of clindathine in vitro and in vivo is superior to ciprofloxacin, which is a broad-spectrum new quinolone antibacterial agent.