论文部分内容阅读
目的观察妇科手术前应用米索前列醇片软化宫颈的有效剂量和时机。方法 160例术前需软化宫颈的患者随机分成A、B、C、D四组,各40例。A组患者术前2 h给予米索前列醇片600μg置于阴道穹窿软化宫颈;B组患者术前16 h给予米索前列醇片600μg置于阴道穹窿软化宫颈;C组患者术前16 h给予米索前列醇片400μg置于阴道穹窿软化宫颈;D组患者术前16 h给予米索前列醇片200μg置于阴道穹窿软化宫颈。观察每组患者宫颈软化的效果及药物不良反应情况。结果术前16 h给药较术前2 h给药软化宫颈的效果更好。术前16 h给药中,D组与C组及B组软化宫颈的效果比较,差异无统计学意义(P>0.05)。D组较C组和B组软化宫颈时药物不良反应发生率比较,差异有统计学意义(P<0.05)。结论妇科手术前需软化宫颈的患者,术前16 h阴道给予米索前列醇片200μg能达到良好效果,可减少药物不良反应的发生,使手术顺利进行。
Objective To observe the effective dosage and timing of misoprostol tablets before gynecological surgery to soften the cervix. Methods One hundred and sixty patients undergoing preoperative cervical softening were randomly divided into four groups (A, B, C and D), 40 in each. In group A, 600 μg of misoprostol was given to the cervix for softening the cervix at 2 hours before operation; 600 μg of misoprostol was given to the vaginal fornix at 16 hours before operation in group B; 16 hours before operation in group C 400 μg of misoprostol was placed in the vagina fornix to soften the cervix. In group D, 200 μg of misoprostol was given to the vaginal fornix to soften the cervix 16 hours before operation. To observe the effect of each group of patients with cervical softening and adverse drug reactions. Results 16 h before surgery than 2 h before surgery to soften the cervix better. 16 h before surgery, D group and C group and B group, the effect of softening the cervix, the difference was not statistically significant (P> 0.05). D group than C and B group softening cervical adverse drug reaction rates, the difference was statistically significant (P <0.05). Conclusions In patients with cervix before gynecological surgery, vaginal administration of misoprostol 200 μg at 16 h before operation can achieve good results, which can reduce the incidence of adverse drug reactions and make the operation proceed smoothly.