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本文报道25例经输精管向附睾方向注射0.3-0.5ml侧鱼肝油酸钠的抗生育效果及其机理探讨。在注射1～13个月后,测定精液常规,精浆中的α-1,4糖苷酶活性,肉毒碱及果糖的含量,血清中FSH、LH、PRL、T、E_2的含量。结果表明:1.糖浆中肉毒碱和α-糖苷酶含量均低于正常生育力者(p<0.001);果糖含量与正常生育力者无显著性差别(p>0.05)。2.血清中FSH、LH、PRL、T、E_2均与正常人无显著性差别(p>0.05)。3.抗生育效果:在25例中有2例女方复孕,在此术后3～4个月进行人流,以后虽然精液中仍有精子,女方均未复孕。因此,本方法可能主要是干扰附睾的功能,从而产生抗生育作用。它是一种安全、有效的男子节育方法。
This article reports 25 cases of vas deferens direction of the epididymis 0.3-0.5ml side injection of sodium morronisal anti-fertility and its mechanism of action. After 1 to 13 months of injection, the contents of α-1,4-glucosidase, carnitine and fructose, serum FSH, LH, PRL, T and E_2 were measured in semen routine and seminal plasma. The results showed that: 1. The contents of carnitine and α-glucosidase in syrup were lower than those in normal fertility (p <0.001). There was no significant difference between fructose and normal fertility (p> 0.05). Serum FSH, LH, PRL, T, E_2 were no significant difference with normal (p> 0.05). 3. Anti-fertility effect: In 25 cases, 2 cases of female pregnancy, after 3 to 4 months after the abortion, although after the sperm are still sperm, the woman did not re-conceive. Therefore, this method may mainly interfere with epididymal function, resulting in anti-fertility effects. It is a safe and effective method of birth control.