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目的分析血清中尿酸(UA)、白蛋白(Alb)、可溶性细胞凋亡因子(s Fas)水平与原发性肝癌的相关性。方法选取原发性肝癌患者120例作为原发性肝癌组,普通肝病患者80例作为普通肝病组,健康者80例作为健康对照组,检测3组研究对象的血清UA、Alb、s Fas水平,分析上述血清指标与原发性肝癌的相关性。结果原发性肝癌组体内血清UA、Alb均低于普通肝癌组和健康对照组(P<0.05),而s Fas水平高于普通肝癌组和健康对照组(P<0.05);UA与Alb水平呈明显正相关(r=0.8854,P<0.05),而UA、Alb与s Fas均为负相关(rUA=-0.7854,rAlb=-0.6987,P<0.05)。结论原发性肝癌患者血清UA与Alb呈正相关,而UA、Alb与s Fas呈负相关,在临床上能作为原发性肝癌的辅助诊断的血清学指标,值得应用。
Objective To analyze the correlation between serum UA, Alb and sFas in primary liver cancer. Methods Totally 120 patients with primary hepatocellular carcinoma (HCC) were selected as primary hepatocellular carcinoma (HCC) group, 80 patients with common hepatic disease as normal liver disease group and 80 healthy individuals as healthy control group. Serum levels of UA, Alb and Fas were detected in three groups of patients, Analysis of the above serum indicators and the correlation of primary liver cancer. Results The levels of serum UA and Alb in primary hepatocellular carcinoma were lower than those in normal liver cancer group and healthy control group (P <0.05), while the level of s Fas was higher in primary hepatocellular carcinoma group than in normal liver cancer group and healthy control group (P <0.05) (R = 0.8854, P <0.05), while UA, Alb and Fas were negatively correlated (rUA = -0.7854, rAlb = -0.6987, P <0.05). Conclusion Serum UA is positively correlated with Alb in patients with primary liver cancer, while UA, Alb and sFas are negatively correlated and can be used clinically as a serological marker in the diagnosis of primary liver cancer.