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为评估新型超短效β-阻滞剂ONO-1101(ON)的心血管作用,作者以犬为动物模型,并与艾司洛尔(ES)进行比较,探讨ON的心脏电生理学、血流动力学和β-阻滞作用。材料与方法实验动物为10kg重的犬,分为ON组(n=6)和ES组(n=6)。麻醉后经右股动脉将导管置于主动脉和左室,测定平均血压(MBP)、左室压最大上升速度(LVdP/dt)和左室舒张末压(LVEDP)。经左颈静脉将热稀释导管置于右室,测定
In order to assess the cardiovascular effects of ONO-1101 (ON), a novel, very short-acting β-blocker, the authors used canine as animal model and compared esmolol with ES to investigate cardiac electrophysiology, Kinetics and β-blockade. MATERIALS AND METHODS Experimental dogs weighing 10 kg were divided into ON group (n = 6) and ES group (n = 6). After anesthesia, the catheter was placed in the aorta and left ventricle via the right femoral artery. The mean blood pressure (MBP), the maximum rate of left ventricular pressure (LVdP / dt) and left ventricular end-diastolic pressure (LVEDP) were measured. The left jugular vein will be placed in the right ventricular thermal dilution catheter determination