目的：研究静脉输注脂肪乳剂对大鼠急性坏死性胰腺炎早期脂质介质的影响。方法：逆行胰管注射３％牛磺胆酸钠建立ＳＤ大鼠坏死性胰腺炎动物模型，通过颈内静脉营养支持７２小时，测定４、４８、７２小时血清淀粉酶、ＴＸＢ２、６ｋｅｔｏＰＧＦ１α、ＰＧＥ２，７２小时行胰腺组织病理学评分。结果：４小时胰腺炎组大鼠血前列腺素类物质均增高，应用脂肪乳剂后可增加血６ｋｅｔｏＰＧＦ１α（糖脂组１５６９±１１７３ｐｍｏｌ／Ｌ；全糖组２９１±６１ｐｍｏｌ／Ｌ，Ｐ＜００５）、ＰＧＥ２（脂肪组６１４±１５ｐｍｏｌ／Ｌ；全糖组２８７±９ｐｍｏｌ／Ｌ，Ｐ＜００５）含量，病理学评分全糖组和糖脂组间无差异。结论：坏死性胰腺炎早期应用脂肪乳剂后可促进抗炎效应前列腺素的产生 Objective: To study the effect of intravenous fat emulsion on early lipid media in rats with acute necrotizing pancreatitis. Methods: Animal models of necrotizing pancreatitis in SD rats were established by injection of 3% sodium taurocholate into the retrograde pancreatic duct. The nutrition was supported by the jugular vein for 72 hours. The serum amylase, TXB2 and 6keto PGF1α, PGE2, 72 hours pancreatic histopathological score. Results: 4h pancreatitis group rats blood prostaglandins were increased after the application of fat emulsion can increase blood 6keto PGF1alpha (glycolipid group 156.9 ± 117 3pmol / L; whole sugar group 29 ± 1 ± 61pmol / L, P <005), PGE2 (614 ± 15pmol / L in fat group and 287 ± 9pmol / L in whole sugar group, P <005) There was no difference between the two groups. Conclusion: Early application of fat emulsion in necrotizing pancreatitis can promote the anti-inflammatory effect of prostaglandin