低密度脂蛋白(LDL)与动脉粥样硬化的关系已熟为人知,但它与癌瘤的关系却研究较少,30年代就有人发现某些癌瘤患者伴有低胆固醇血症。现知血浆中的胆固醇主要存在于LDL中,而LDL主要是通过受体介导进入细胞降解的。采用密度梯度离心法分离LDL,用Iodogen法~(125)I二标记LDL,测定食管癌、胃癌的癌组织及相应的同体正常组织LDL受体水平。结果如下:(1)癌瘤组织蛋白质、DNA含量均明显高于正常组织;(2) The relationship between low density lipoprotein (LDL) and atherosclerosis has become well known, but its relationship with cancer has been less studied. In the 1930s, some patients with cancer were found to have hypocholesterolemia. It is now known that plasma cholesterol is predominantly present in LDL, whereas LDL is mainly mediated through the receptor into the cell for degradation. LDL was isolated by density gradient centrifugation and LDL was labeled with Iodogen method (125 I). The levels of LDL receptor in esophageal cancer, gastric cancer and corresponding normal tissues were determined. The results are as follows: (1) The protein and DNA content of cancer tissues were significantly higher than that of normal tissues; (2)