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为系统研究1,2,4-三嗪类化合物干扰核酸代谢的规律,曾经研究了一些三嗪类化合物的制备及其性质。 李钧等初次发现6-甲基-3-甲硫基-5-羟基-1,2,4-三嗪(Ⅰ)在无水吡啶中,与对甲苯磺酰氯作用,直接滤得N-[5-(3-甲硫基-6-甲基)-1,2,4-三嗪基]氯化吡啶嗡盐(Ⅱ),Ⅱ在微量吡啶催化下,经水分解得产物推论为N~4-[5-(3-甲硫基-6-甲基)-1,2,4-三嗪基]-3-甲硫基-6-甲基-5-氧代-4,5-二氢-1,2,4-三嗪(Ⅲ),然后他们研究了Ⅱ的胺解和Ⅲ的醇解
In order to systematically investigate the regularity that 1,2,4-triazine interfere with nucleic acid metabolism, the preparation and properties of some triazine compounds have been studied. Li Jun and other first discovered that 6-methyl-3-methylthio-5-hydroxy-1,2,4-triazine (Ⅰ) in anhydrous pyridine, and tosyl chloride role, direct filtration N- [ Pyridine chloride salt (Ⅱ) 5- (3-methylthio-6-methyl) -1,2,4-triazinyl] pyridinium chloride was catalyzed by trace amount of pyridine, 4- [5- (3-methylthio-6-methyl) -1,2,4-triazinyl] -3-methylthio-6-methyl-5-oxo-4,5-bis Hydrogen-1,2,4-triazine (III), and then they studied the amine hydrolysis of II and the alcoholysis of III