动脉硬化和骨质疏松是两种常见的老年病,两者具有相同的危险因素和病理生理机制。护骨素、基质G la蛋白、维生素D、甲状旁腺素、骨桥蛋白、氧化脂质等均参与或加速了两者的共同发病。基于两者相似的发病机制,使用他汀类药物、双磷酸盐、护骨素等药物可同时对骨量丢失和动脉硬化起保护作用,这是今后治疗动脉硬化和骨质疏松的一个新思路。 Arteriosclerosis and osteoporosis are two common forms of geriatric disease, both of which have the same risk factors and pathophysiological mechanisms. Osteoprotegerin, matrix G la protein, vitamin D, parathyroid hormone, osteopontin, oxidized lipids, etc. are involved in or accelerate the common incidence of the two. Based on their similar pathogenesis, the use of statins, bisphosphonates, osteoprotegerin and other drugs can simultaneously protect bone loss and atherosclerosis, which is a new idea for the future treatment of atherosclerosis and osteoporosis.