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自80年代初利福平广泛用于结核病化疗以来,类赫氏反应病例报告有增多趋势。有人曾综合报道国内外成人类赫氏反应161例[1]。我院传染科1986年7月-1995年6月收治的515例小儿结核病中,发生该反应7例,现报告如下。 临床资料 一、一般资料男5例,女2例。年龄10-13岁。7例PPD试验均为强阳性。1例痰菌阳性,1例痰液PCR检测TB-DNA阳性。 二、分型及用药x线胸片显示原发综合征1例,粟粒型肺结核3例,浸润性肺结核3例。原发综合征采用链霉素(s)20~30mg/kg·d,异菸肼(H)
Since the early 1980s, rifampicin has been widely used in the treatment of tuberculosis, the incidence of Herz-like reactions has been increasing. Some people have reported a total of 161 domestic and foreign adult Hertzian reactions [1]. In our hospital infectious disease department July 1986-June 1995 515 cases of pediatric tuberculosis, the reaction occurred in 7 cases, are as follows. First, the general information of 5 males and 2 females. Aged 10-13 years old. Seven cases of PPD test were strongly positive. 1 case of sputum positive, 1 case of sputum PCR detection of TB-DNA positive. Second, the type and medication X-ray showed primary syndrome in 1 case, miliary tuberculosis in 3 cases, 3 cases of infiltrative pulmonary tuberculosis. Primary syndrome with streptomycin (s) 20 ~ 30mg / kg · d, isoniazid (H)