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近年来证实急性冠状动脉综合征(ACS)早期应用他汀类药物治疗除可增加患者坚持长期服药治疗的依从性,更主要的是已证实他汀类药物除有调/降脂效益,也有多方面心血管保护作用,包括稳定斑块、改善内皮功能、减少炎症反应及抑制血栓形成等,从而降低心脑血管事件发生,而且用药安全[1]。本研究旨在观察两种不同剂量辛伐他汀在ACS早期应用的有效性、安全性和在预防心血管事件中的作用。
In recent years, confirmed that the early application of statins in patients with acute coronary syndrome (ACS) in addition to increasing adherence to long-term adherence to treatment, but more importantly, has confirmed that statins in addition to lipid-lowering / lipid-lowering benefits, there are many heart Vascular protection, including stable plaque, improve endothelial function, reduce inflammation and inhibit thrombosis, thereby reducing the occurrence of cardiovascular and cerebrovascular events, and drug safety [1]. The purpose of this study was to investigate the efficacy and safety of two different doses of simvastatin in the early stage of ACS and its role in the prevention of cardiovascular events.