论文部分内容阅读
目的：观察羟乙膦酸二钠间断和周期性防治绝经后骨质疏松的；临床疗效。方法：７２例腰椎（Ｌ２～４）骨矿密度（ＢＭＤ）低于本地区 ２０～４０岁健康女性均值减１．０标准差的绝经后妇女，双盲随机分为两组各３６例。羟乙膦酸二钠治疗组 ３６例，给予羟乙膦酸二钠４００ｍｇ／日，连服 ２周，停药 １０周，重复 ３次共 ３６周。对照组服安慰剂，程序同治疗组。观察期间两组均每日加服钙剂和维生素Ｄ。试验前后用双能Ｘ线吸收法（ＤＥＸＡ）测定腰椎和股骨ＢＭＤ，同时测定血钙（Ｃａ）、磷（Ｐ）、碱性磷酸酶（ＡＬＰ）、抗酒石酸盐酸性磷酸酶（ＴＲＡＰ）、空腹尿钙／肌酐比值（Ｃａ／Ｃｒ）和羟脯氨酸／肌配比值（Ｈｙｐ／Ｃｒ）。根据腰椎 ＢＭＤ变化和骨癌症状改善情况综合判断疗效。结果：治疗组 ４个部位ＢＭＤ均增加（Ｐ＜０．０５或０．０１），血ＴＲＡＰ降低（Ｐ＜０．０１），综合总有效率为９１．７％。结论：羟乙膦酸二钠防治绝经后骨质疏松有明显疗效。
Objective: To observe intermittent and periodic prevention and treatment of etidronate disodium in postmenopausal osteoporosis. Methods: Bone mineral density (BMD) in 72 patients with lumbar spine (L2 ~ 4) was lower than 1.0 standard deviations of average standard deviation of healthy women aged 20 ~ 40 in this region. Etidronate disodium treatment group of 36 patients given etidronate disodium 400mg / day, and even for 2 weeks, withdrawal 10 weeks, repeated 3 times for a total of 36 weeks. Control group placebo, the same procedure with the treatment group. During the observation period, both groups supplemented with calcium and vitamin D daily. The BMD of lumbar vertebrae and femur were measured by dual energy X-ray absorptiometry (DEXA) before and after the test. The levels of serum Ca, P, ALP, TRAP, fasting Urinary calcium / creatinine ratio (Ca / Cr) and hydroxyproline / muscle ratio (Hyp / Cr). According to changes in lumbar BMD and bone cancer symptoms to improve the comprehensive assessment of the efficacy. Results: The BMD of four sites in the treatment group increased (P <0.05 or 0.01) and the blood TRAP decreased (P <0.01). The total effective rate was 91.7%. Conclusion: Etidronate disodium has a significant therapeutic effect on postmenopausal osteoporosis.