食管癌是常见恶性肿瘤之一,早期诊断率低,70%～80%患者就诊时已属晚期。虽然外科治疗技术的提高、联合新药化疗、术前新辅助放化疗、同期放化疗,增加了局部晚期食管癌的缓解率和肿瘤切除率,生存率亦略有提高,但预后仍差,需要新的治疗手段来提高食管癌疗效。随着肿瘤分子生物学研究的进展,作用于肿瘤细胞特定的靶点来治疗肿瘤的分子靶向治疗,具有靶向选择性、高效性、低毒性 Esophageal cancer is one of the common malignant tumors, the early diagnosis rate is low, 70% to 80% of patients are already in advanced stage of treatment. Although the improvement of surgical treatment, combined with new drug chemotherapy, preoperative neoadjuvant chemoradiotherapy, concurrent chemoradiotherapy, increased local advanced esophageal cancer remission rate and tumor resection rate, survival rate also increased slightly, but the prognosis is still poor, the need for new Treatment to improve the efficacy of esophageal cancer. With the advancement of research in molecular biology of tumors, molecular targeted therapies that target specific targets of tumor cells for the treatment of tumors, have the advantages of targeting selectivity, high efficiency and low toxicity