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方法:选取弋矶山医院血液净化中心符合RSL诊断标准的常规血液透析患者60例作为研究对象，将其随机分为对照组(采用加巴喷丁治疗，n n＝30)和观察组(采用维生素Bn 12联合加巴喷丁治疗，n n＝30) ，观察治疗前、后国际不安腿综合征研究组(IRLSSG)调查问卷评分、匹茨堡睡眠质量指数量表(PSQI)评分变化以及SF-36量表评分变化。n 结果:治疗后观察组IRLSSG评分较对照组下降更明显，差异有统计学意义(n P<0. 05)。治疗后两组PSQI评分均较治疗前明显下降，观察组PSQI评分较对照组下降更加明显，差异有统计学意义(n P <0.05)。治疗后观察组生活质量评估SF-36量表评分提升较对照组更为明显，差异有统计学意义( n P<0.05)。两组均无明显不良反应发生。n 结论:维生素Bn 12联合加巴喷丁较单独使用加巴喷丁可进一步改善并发不安腿综合征的维持性血液透析患者的生存质量，值得推广。n “,”Objective:To observe the clinical effect of Vitamin Bn 12 combined with gabapentin on restless legs syndrome(RLS) in maintenance hemodialysis patients.n Methods:A total of 60 regular dialysis patients who met the diagnostic standard of RLS in Blood Purification Center of Yijishan Hospital were randomly divided into the control group (treated with gabapentin, n n=30) and the observation group (treated with Vitamin Bn 12 and gabapentin, n n=30). The changes of IRLSSG, PSQI and SF-36 were observed before and after the treatment.n Results:The IRLSSG score of the observation group was significantly lower than that of the control group (n P<0.05), and the PSQI score of the observation group was significantly lower than that of the control group (n P<0.05). Compared with the control group, the improvement of the observation group was more significant, and the difference was statistically significant (n P<0.05). There was no significant adverse reactions in both groups.n Conclusions:Compared with gabapentin alone, Vitamin Bn 12 combined with gabapentin can further improve the quality of life of maintenance hemodialysis patients with restless legs syndrome.n