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目的:评价注射用还原型谷胱甘肽对重症乙型肝炎患者100例的临床疗效。方法:选取2015年1—12月间收治的重症乙型肝炎患者100例,采用随机分组法将其分为观察组和对照组,每组50例;对照组患者给予注射用维生素C、注射用促肝细胞生长素、干扰素-γ1b和多烯磷脂酰胆碱注射液治疗,观察组患者在对照组基础上加用注射用还原型谷胱甘肽治疗;比较两组患者治疗后的总有效率和治疗前和治疗28 d时的肝功能各指标的变化情况。结果:两组患者治疗后总胆红素(TBil)、丙氨酸转氨酶(ALT)测得值均低于治疗前,而胆碱酯酶(CHE)、血清总蛋白(TP)均高于治疗前;观察组患者治疗后的TBil、ALT测得值低于对照组(P<0.05),总有效率为72.00%显著高于对照组为40.00%(P<0.05)。结论:采用谷胱甘肽治疗重症乙型肝炎患者,能显著改善肝功能各指标。
Objective: To evaluate the clinical efficacy of glutathione for injection in treating 100 cases of severe hepatitis B patients. Methods: One hundred patients with severe hepatitis B who were admitted from January to December in 2015 were selected and randomly divided into observation group and control group, 50 cases in each group. Patients in control group were given vitamin C for injection, Hepatocyte growth-promoting factor, interferon-γ1b and polyene phosphatidylcholine injection treatment, the observation group patients in the control group plus the use of reduced glutathione for injection therapy; compared two groups of patients after treatment, there are always Efficiency and changes of liver function indexes before treatment and 28 days after treatment. Results: The levels of total bilirubin (TBil) and alanine aminotransferase (ALT) were lower in both groups before treatment than those before treatment, while CHE and TP were higher than those before treatment (P <0.05). The total effective rate was 72.00%, which was significantly higher than that of the control group (40.00%, P <0.05). Conclusion: The treatment of severe hepatitis B patients with glutathione can significantly improve the indexes of liver function.