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目的:探讨孕中期母体血清甲胎蛋白筛查对降低出生缺陷的意义。方法:用德国DRG公司提供的酶免试剂与分析软件对15 4 2例孕15- 2 0 + 6w的孕妇进行了AFP筛查。结果:15 4 2例孕妇中共检出开放性神经畸形高风险(AFP >2 .0MOM) 4 2例,占2 .7% ,4 2例中已确诊胎儿有明显异常的为6例;AFP <0 .5MOM的为4 4例。结论:孕中期筛查AFP对降低出生缺陷有重要意义。
Objective: To investigate the significance of screening for alpha-fetoprotein in the second trimester of pregnancy to reduce birth defects. METHODS: AFP screening was performed on 1542 pregnant women with 15-20 + 6w pregnant women using enzyme-free reagents and analysis software provided by German DRG company. Results: Forty-two pregnant women were found to have 42 cases of high risk of open neurological abnormalities (AFP> 2.0MOM), accounting for 2.7%. Of the 42 cases, 6 cases were diagnosed as having abnormal fetuses. AFP < 0. 5MOM for 4 4 cases. Conclusion: Screening for AFP during the second trimester is of great importance in reducing birth defects.