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目的:研究口服酪酸菌对肝硬化患者细胞和体液免疫紊乱的调节作用.方法:给肝硬化患者口服酪酸菌制剂,每次一克,每日三次,共三个月.治疗期间禁用任何抗菌药物及影响免疫的药物,检测治疗前后周围静脉血之CD3,CD4,CD8,NK及免疫球蛋白A,G,M.结果:治疗三个月后血浆免疫球蛋白G和A的水平明显降低(P<0.05).结论:口服酪酸菌可通过抑制肠道有害菌群过度生长,减少有害抗原进入人体循环,从而改善肝硬化患者体液免疫紊乱状态.
Objective: To study the effect of oral butyric acid bacteria on the regulation of cellular and humoral immune disorders in patients with cirrhosis.Methods: Patients with cirrhosis were given oral butyric acid, one gram three times a day for three months.All antibiotics And immune-affecting drugs were detected before and after treatment of peripheral venous blood of CD3, CD4, CD8, NK and immunoglobulin A, G, M. Results: After three months of plasma immunoglobulin G and A levels were significantly lower (P <0.05) .Conclusion: Oral butyric acid bacteria can improve humoral immune disorders in patients with liver cirrhosis by inhibiting the excessive growth of harmful intestinal flora, reducing the entry of harmful antigens into the human body.