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本文观察了吡喹酮对各期日本血吸虫病患者肝脏的副作用。作者通过1978～1981三年中所收治的664例血吸虫病患者的分析,认为吡喹酮引起的肝脏损害既少且轻。应用吡喹酮前肝功能正常,而用药后出现异常者占总例数的2.29％。在治疗前肝功能已有异常或合并肝脏夹杂症者中,81.4％能良好地耐受吡喹酮治疗;4.3％治后肝功能损害加重,但经辅肝药物治疗后迅速康复。上述资料提示吡喹酮远较其它传统的抗血吸虫病药物为优,可用于肝脏有损害的血吸虫病患者。
This article looked at the side effects of praziquantel on the liver in patients with various stages of schistosomiasis japonica. Based on an analysis of 664 patients with schistosomiasis admitted in the three-year period from 1978 to 1981, the authors concluded that praziquantel-induced liver damage was both less and less severe. Before the application of praziquantel normal liver function, and medication abnormalities accounted for 2.29% of the total number of cases. In the treatment of liver dysfunction or liver complications, 81.4% can well tolerate praziquantel treatment; 4.3% after treatment of liver dysfunction increased, but the rapid recovery after treatment with hepatic drugs. The above data suggest that praziquantel is superior to other traditional anti-schistosomiasis drugs and can be used in patients with liver damage schistosomiasis.