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采用新合成的人体骨组织替代材料羟基聚磷酸钙钠和羟基磷灰石、生物玻璃陶瓷、钛合金分别植入９只家犬下颌骨拔牙创中，植入术后半月、１月和３月用Ｘ线检查、扫描电镜和Ｘ线能谱分析等方法来考察这些材料对骨愈合过程的影响。结果表明：这４种材料均与骨界面间形成骨性结合，尤以羟基聚磷酸钙钠早期易形成骨性结合界面。在实验早期，材料－骨界面的钙、磷含量低，而硫、硅含量高。随时间延长，骨界面的钙、磷含量逐渐增高，而硫、硅含量逐渐下降，预示着骨界面的钙化程度逐渐加大。
The newly synthesized human bone tissue substitute materials of sodium hydroxy polyphosphate and hydroxyapatite, bio-glass ceramic, titanium alloy were implanted in the mandibular extraction of nine domestic dogs, implantation, a month after surgery, January and March X-ray examination, scanning electron microscopy and X-ray energy spectrum analysis and other methods to examine the impact of these materials on the healing process. The results showed that these four materials all formed osseointegration with the bone interface, especially calcium hydroxyapatite could easily form the osseointegration interface at early stage. Early in the experiment, the material-bone interface has low levels of calcium and phosphorous but high levels of sulfur and silicon. With the extension of time, the contents of calcium and phosphorus in the bone interface gradually increased, while the contents of sulfur and silicon decreased gradually, indicating the degree of calcification in the bone interface gradually increased.