急性肝功能衰竭的治疗原则可归纳为:(1)去除毒性物质;(2)作为肝脏功能代偿的支持疗法;(3)阻止肝坏死进展,促进残存肝细胞功能恢复和再生;(4)辅助疗法和积极处理并发症。本文就以上几方面的进展作一介绍。去除中毒物质一般认为,诱发急性肝能功衰竭以及肝衰时出现的毒性物质不但能抑制肝细胞再生,而且是引起各种并发症的原因。这些毒性物质包括氨、硫醇、低级脂肪酸(C_4～C_6)、活性胺(酪胺、(鱼章)胺及β-苯乙醇胺等)、甲基硫醇等中枢神经系统致毒物质和与蛋白质结合 The principles of treatment of acute liver failure can be summarized as: (1) removal of toxic substances; (2) as supportive therapy of hepatic functional compensation; (3) prevention of progression of liver necrosis and promotion of functional recovery and regeneration of residual liver cells; (4) Adjuvant therapy and aggressive management of complications. This article introduces the progress in the above aspects. Removal of toxic substances is generally believed that induced acute liver failure and liver toxicity occurs when the substance can not only inhibit liver cell regeneration, but also cause a variety of complications. These toxic substances include ammonia, thiols, lower fatty acids (C_4 ~ C_6), active amines (tyramine (fish cap) amine and β-phenylethanolamine, etc.), methyl mercaptan and other central nervous system toxic substances and proteins Combined