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目的分析矽肺患者呼吸系统感染金黄色葡萄球菌的耐药情况,为临床治疗矽肺并发呼吸系统感染提供依据。方法用K-B法做细菌药敏试验,Whonet5软件判断、统计细菌药敏结果。结果在送检的矽肺患者呼吸系统痰液标本检出的临床常见病原菌中,金黄色葡萄球菌的检出率为30.0%。痰液中检出的金黄色葡萄球菌,对临床常用于治疗呼吸系统感染的药物阿莫西林/舒巴坦、头孢唑啉、头孢曲松、呋喃妥因的耐药率分别为:67.0%、62.5%、75.2%和42.8%;呼吸系统标本痰液中检出的金黄色葡萄球菌对红霉素、阿奇霉素、氧氟沙星等,均表现出较高的耐药率。对万古霉素的耐药率为0,对阿米卡星的耐药率为4.2%。结论矽肺患者合并呼吸系统感染的痰液标本中,金黄色葡萄球菌的检出率较高,而且检出的金黄色葡萄球菌,对临床各常用药物的耐药率也存在较大的差异。
Objective To analyze the resistance of patients with silicosis to respiratory infection of Staphylococcus aureus and provide the basis for clinical treatment of silicosis complicated with respiratory system infection. Methods K-B method for bacterial susceptibility testing, Whonet5 software to determine, the results of bacterial susceptibility. Results The detection rate of Staphylococcus aureus was 30.0% among the common clinical pathogens detected in respiratory sputum of patients with silicosis. Staphylococcus aureus detected in sputum were resistant to amoxicillin / sulbactam, cefazolin, ceftriaxone and nitrofurantoin, which were commonly used clinically in the treatment of respiratory infections, respectively: 67.0%, 62.5% , 75.2% and 42.8%, respectively. Staphylococcus aureus detected in sputum of respiratory system showed high resistance rate to erythromycin, azithromycin and ofloxacin. The rate of resistance to vancomycin was 0 and the rate of resistance to amikacin was 4.2%. Conclusion The detection rate of Staphylococcus aureus is high in the sputum specimens of patients with silicosis who have respiratory infections, and the detection rate of Staphylococcus aureus is also different to the commonly used drugs in clinical practice.