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本文报告正常和高脂血家兔血清低密度脂蛋白理化性质的比较。高脂血家兔血清脂蛋白超速离心图不同于正常家兔。高脂血家兔血清低密度脂蛋白的理化性质在颗粒大小、密度、电泳迁移率、上浮速度和脂质蛋白质组成方面均不同于正常家兔血清低密度脂蛋白。特别是其中的apoE可能使高脂LDL结合于平滑肌细胞大于正常LDL,这也表明饮食脂肪和胆固醇的变化可以引起家兔血清脂蛋白组成和理化性质的变化,可导致脂蛋白代谢在细胞和分子水平上的差异。
This article reports the physicochemical properties of serum LDL in normal and hyperlipidemic rabbits. Hyperlipidemic rabbit serum lipoprotein ultracentrifugation diagram is different from normal rabbits. Physiochemical properties of serum LDL in hyperlipidemic rabbits differ from normal rabbit serum LDL in terms of particle size, density, electrophoretic mobility, ascending velocity and lipid protein composition. In particular, apoE may bind high-fat LDL to smooth muscle cells greater than normal LDL, which also indicates that changes in dietary fat and cholesterol may cause changes in the composition and physicochemical properties of serum lipoproteins in rabbits, resulting in the metabolism of lipoproteins in cells and molecules The difference in level.