论文部分内容阅读
目的探讨喜炎平联合锌制剂、利巴韦林治疗小儿轮状病毒腹泻的临床疗效及安全性。方法回顾性分析2015年1月-2016年5月我院儿科收治的96例轮状病毒腹泻患儿临床资料,随机双盲法分为对照组和研究组,对照组(48例)给予利巴韦林支持治疗,研究组(48例)在对照组的基础上联合喜炎平与葡萄糖酸锌口服液进行治疗,比较分析2组临床症状缓解时间及临床疗效。结果研究组患儿的治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组患儿的发热、恶心呕吐、腹痛、腹泻缓解时间均明显低于对照组;神经生长因子(NGF)、神经营养因子(NTF)、脑源性神经营养因子(BDNF)含量均明显高于对照组;治疗后从15min开始体温明显低于治疗前,明显快于对照组,差异均有统计学意义(P<0.05)。结论喜炎平联合锌制剂与利巴韦林用药治疗小儿轮状病毒腹泻有效率高,明显缩短症状持续时间,无明显不良反应,效果非常显著值得临床推广应用。
Objective To investigate the clinical efficacy and safety of Xiyanping combined with zinc preparations and ribavirin in treating pediatric rotavirus diarrhea. Methods The clinical data of 96 children with rotavirus diarrhea treated in our hospital from January 2015 to May 2016 were retrospectively analyzed. The patients were divided into control group and study group by random double-blind method. The control group (48 cases) Waring supportive treatment, the study group (48 cases) on the basis of the control group combined with Xiyanping and oral gluconate oral treatment, comparative analysis of two groups of clinical symptoms and clinical efficacy of remission. Results The total effective rate of treatment group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). The fever, nausea and vomiting, abdominal pain and diarrhea relief time in study group were significantly lower than those in control group. The content of nerve growth factor (NGF), neurotrophic factor (NTF) and brain-derived neurotrophic factor (BDNF) The body temperature in the control group was significantly lower than that before treatment from 15min after treatment, and the difference was statistically significant (P <0.05). Conclusion Xiyanping combined with zinc and ribavirin treatment of pediatric rotavirus diarrhea efficient, significantly shortened the duration of symptoms, no significant adverse reactions, the effect is very worthy of clinical application.