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目的探讨HIV感染者外周血T淋巴细胞亚群数量及功能与疾病进展的关系。方法通过流式细胞仪法检测健康志愿者与HIV感染不同程度患者的外周血T淋巴细胞亚群CD 3+、CD 4+、CD 8+T细胞数量及功能,比较不同HIV感染者T细胞亚群数量的差异。结果 LTNP组、HIV组与AIDS组的CD 3+、CD 4+数量均显著降低,CD 4+/CD 8+倒置明显,且均与对照组比较存在显著性差异(P<0.01),且随着HIV感染的加重,CD 4+数量显著降低,CD 4+/CD 8+比值倒置愈加显著,CD 8+及CD 3+数量降低。结论 HIV感染后,CD 4+T细胞数量显著降低,CD 4+/CD 8+比值也随之降低,且随着疾病进展,变化显著,提示T细胞亚群数量及功能变化可能对疾病进展情况具有重要临床指示作用。
Objective To investigate the relationship between the number and function of T lymphocyte subsets and the progression of disease in HIV-infected peripheral blood. Methods The numbers and functions of CD 3 +, CD 4 + and CD 8 + T lymphocytes in peripheral blood of healthy volunteers and patients with different degrees of HIV infection were detected by flow cytometry. T cell subsets Differences in the number of groups. Results The numbers of CD 3 + and CD 4+ in the LTNP group, the HIV group and the AIDS group were significantly decreased, and the levels of CD 4 + / CD 8+ were significantly reversed (all P <0.01) With the increase of HIV infection, the number of CD 4+ decreased significantly, and the ratio of CD 4 + / CD 8+ became more significant. The number of CD 8+ and CD 3+ decreased. Conclusions The number of CD 4 + T cells and the ratio of CD 4 + / CD 8+ in HIV-infected patients decreased significantly with the progression of the disease, suggesting that the number and functional changes of T-cell subsets may play an important role in disease progression Has important clinical indication.