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本工作研究肠道内给654-2(药物不进入全身循环)对失血性休克的发展过程及血浆溶酶体酶(组织蛋白酶)含量的影响。实验在成年雄猫(2.8-3.7kg)进行,全麻下在十二指肠中部和小肠下端各置一瘘管,并阻断肠系膜上动脉(SMA)下将含0.5mg/ml的654-2-生理盐水按25ml/kg从瘘管灌入小肠胜,30分钟后排出654-2并以50ml/mg生理盐水灌洗小肠腔以排降654-2。对照组不给药物,只给等量生理盐水。给药组使随
This work is to study the effect of intestinal administration of 654-2 (drug does not enter the systemic circulation) on the development of hemorrhagic shock and plasma lysosomal enzyme (cathepsin) content. Experiments were performed in adult male cats (2.8-3.7 kg) under general anesthesia with a fistula at the middle part of the duodenum and the lower part of the small intestine, respectively, and a block of 0.54 mg / ml of 654-2 - Saline was instilled into the small intestine at a rate of 25 ml / kg from the fistula. After 30 minutes 654-2 was excreted and the intestinal lumen was drained with 50 ml / mg saline to drain 654-2. Control group did not give drugs, only to the same amount of saline. Administration group to follow